Chonluten
Also called EDG; Glu-Asp-Gly
A three-amino-acid bioregulator peptide studied for effects on inflammatory signaling. It is often called a lung peptide, but there is no evidence it treats respiratory disease in people.
Overview
What it is
A synthetic tripeptide of glutamic acid, aspartic acid and glycine from the Khavinson research program. It is a different peptide from Bronchogen.
How it works
In a 2022 study of THP-1 immune cells, Chonluten changed inflammatory signaling and cell growth, with responses that depended on conditions. Some treated cells also showed signs of programmed cell death.
What the research shows
A patent describes protective effects in stomach-cell and rat ulcer models, and another patent reports better tolerance of low oxygen in 80 healthy young men. Patent reports are not the same as peer-reviewed clinical trials.
Studied for
- Inflammatory signaling in immune cellslab
- Stomach ulcer modelspatent, animal
- Low-oxygen tolerancepatent, human
Safety and regulatory status
Safety and side effects
No reliable human side-effect rate or long-term safety data. The cell-death finding is relevant to further safety research.
Regulatory status
Not approved by the FDA for any use.
Mixing and dosing reference
Reference information only. Read before using this section.
Chonluten (20 mg Vial) Dosage Protocol
- Vial
- 20 mg Chonluten
- Add diluent
- 3 mL
- Concentration
- 6.67 mg/mL
- 1 unit (U-100)
- 66.67 mcg in 0.01 mL
- Route
- Subcutaneous
- How often
- Once per day (subcutaneous).
- Typical range
- 250–4,000 mcg once daily (gradual titration over 8–16 weeks).
- Cycle length
- 8–16 weeks; shorter durations (8–12 weeks) acceptable.
Standard / Gradual Approach
| Week | Daily Dose (mcg) | Units (per injection) (mL) |
|---|---|---|
| Weeks 1–2 | 250 mcg (0.25 mg) | 3.75 units (0.0375 mL) |
| Weeks 3–4 | 500 mcg (0.5 mg) | 7.5 units (0.075 mL) |
| Weeks 5–6 | 1,000 mcg (1 mg) | 15 units (0.15 mL) |
| Weeks 7–8 | 1,500 mcg (1.5 mg) | 22.5 units (0.225 mL) |
| Weeks 9–10 | 2,000 mcg (2 mg) | 30 units (0.30 mL) |
| Weeks 11–12 | 3,000 mcg (3 mg) | 45 units (0.45 mL) |
| Weeks 13–14 | 4,000 mcg (4 mg) | 60 units (0.60 mL) |
| Weeks 15–16 | 4,000 mcg (4 mg) | 60 units (0.60 mL) |
How to mix
- Draw 3.0 mL bacteriostatic water with a sterile syringe.
- Inject slowly down the vial wall; avoid foaming.
- Gently swirl/roll until dissolved (do not shake).
- Label and refrigerate at 2–8 °C (35.6–46.4 °F), protected from light.
Dosing details
- Start: 250 mcg daily; increase by 250–500 mcg every 1–2 weeks as tolerated.
- Target: Up to 4,000 mcg daily by Weeks 13–16.
- Frequency: Once per day (subcutaneous).
- Cycle Length: 8–16 weeks; shorter durations (8–12 weeks) acceptable.
- Timing: Any consistent time; rotate injection sites.
Storage
- Lyophilized (short‑term): Refrigerate at 4 °C (39.2 °F) in dry, dark conditions.
- Lyophilized (long‑term): Store at −20 °C (−4 °F) or colder; minimize moisture exposure.
- Reconstituted: Refrigerate at 2–8 °C (35.6–46.4 °F); use within days to weeks and avoid freeze–thaw.
- Allow vials to reach room temperature before opening to reduce condensation uptake.
Administration technique
- Clean the vial stopper and skin with alcohol; allow to dry.
- Pinch a skinfold; insert the needle at 45° into subcutaneous tissue using a 25–27 gauge, ⅝‑inch needle.
- Do not aspirate for subcutaneous injections; inject slowly and steadily.
- Rotate sites systematically (abdomen, thighs, upper arms) to avoid lipohypertrophy.
Important notes
- Use new sterile insulin syringes; dispose in a sharps container.
- Rotate injection sites (abdomen, thighs, upper arms) to reduce local irritation.
- Inject slowly; wait a few seconds before withdrawing the needle.
- Document daily dose and site rotation to maintain consistency.
- For initial low‑volume doses (≤10 units), use 30‑ or 50‑unit insulin syringes for improved accuracy.
Protocol source: PeptideDosages.com
Common questions
Is Chonluten anti-inflammatory?
It affects inflammatory pathways in the lab; that is not proof it treats inflammation in people.
Does it regenerate the lungs?
That has not been shown.
Can it replace an inhaler?
No. Keep following your prescribed treatment and asthma or COPD action plan.
Related in Healthy Aging
Sources and further reading (4)
- Avolio F, et al. Peptides regulating proliferative and inflammatory pathways in THP-1 cells. Int J Mol Sci, 2022.
- Ashapkin VV, et al. Epigenetic mechanisms of peptidergic regulation during aging. Biochemistry (Moscow), 2015.
- NHLBI. Asthma treatment and action plan; COPD treatment.
- Source summary: PeptideDosages.com research overview (rewritten for NVO).