Cardiogen
Also called AEDR; Ala-Glu-Asp-Arg
A four-amino-acid bioregulator peptide studied in heart-tissue cultures and animals. It has not been shown to repair the human heart or treat cardiovascular disease.
Overview
What it is
A synthetic tetrapeptide of alanine, glutamic acid, aspartic acid and arginine. It is unrelated to CardioGen-82, a radioactive imaging agent used in heart PET scans.
How it works
In heart tissue from young and old rats, it increased cell growth and lowered p53, a protein tied to programmed cell death. In mouse connective-tissue cells, it raised structural proteins such as actin, tubulin and lamins.
What the research shows
A patent describes protective effects in rat heart-injury experiments. A rat study with transplanted sarcoma reported more tumor-cell death and slower tumor growth. No human treatment trials were identified.
Studied for
- Heart tissue cell growthrats, lab
- Cell structure proteinsmouse cells
- Heart injury modelspatent, animal
Safety and regulatory status
Safety and side effects
No dependable human side-effect data exist. Effects on cell growth and death need careful study, especially for anyone with cancer. Interactions with heart medications are unknown. Never change prescribed heart medication based on peptide claims.
Regulatory status
Not approved by the FDA for any use.
Mixing and dosing reference
Reference information only. Read before using this section.
Cardiogen (20 mg Vial) Dosage Protocol
- Vial
- 20 mg Cardiogen
- Add diluent
- 3 mL
- Concentration
- 6.67 mg/mL
- 1 unit (U-100)
- 66.67 mcg in 0.01 mL
- Route
- Subcutaneous
Community-Reported Use Calculations
| Research Period | Amount per Administration | U-100 Units (mL) |
|---|---|---|
| 10 days | 1 mg | 15 units (0.15 mL) |
| 20 days | 1 mg | 15 units (0.15 mL) |
| 10 days | 2 mg | 30 units (0.30 mL) |
| 20 days | 2 mg | 30 units (0.30 mL) |
How to mix
- Clean the vial stopper and diluent stopper with alcohol; allow both to dry.
- Draw exactly 3.0 mL of bacteriostatic water with a new sterile syringe, then inject it slowly down the inside wall of the vial.
- Gently swirl or roll until dissolved. Do not shake.
- Label the vial with compound, concentration, and reconstitution date. Refrigerate at 2–8 °C (36–46 °F) and protect from light.
Protocol source: PeptideDosages.com
Common questions
Is Cardiogen the same as CardioGen-82?
No. CardioGen-82 is a diagnostic imaging agent.
Does Cardiogen rebuild heart muscle?
That has not been shown in people.
Is it interchangeable with other bioregulators?
No. Different sequences have separate evidence.
Related in Healthy Aging
Sources and further reading (5)
- Khavinson VK, et al. AEDR stimulates cytoskeletal and nuclear matrix proteins. Bull Exp Biol Med, 2012.
- Chalisova NI, et al. Cardiogen and myocardial tissue culture from young and old rats. Adv Gerontol, 2009.
- Levdik NV, Knyazkin IV. Tumor-modifying effect of cardiogen on M-1 sarcoma in rats. Bull Exp Biol Med, 2009.
- NHLBI. Heart failure treatment.
- Source summary: PeptideDosages.com research overview (rewritten for NVO).