Estradiol Gel
Transdermal estradiol gel
A daily estrogen gel for hot flashes and night sweats.
About Estradiol Gel
A measured amount of gel is rubbed onto the skin once a day. Like the patch, it is absorbed through the skin. Let it dry before skin-to-skin contact, and wash hands after applying. Anyone with a uterus also needs a progestogen.
Read the full Estradiol guide: research, safety and sources →
How it works
- Complete a short online visit. Answer health questions on our telehealth partner's secure site. Some treatments need lab work first.
- A licensed provider reviews it. They decide whether Estradiol Gel is safe and appropriate for you and may message you with questions.
- If prescribed, it ships to you from a licensed U.S. pharmacy, with ongoing check-ins and refills through your provider.
Important safety information
Estrogen labels carry boxed warnings: estrogen alone raises the risk of endometrial cancer in people with a uterus (a progestogen is added to lower it), and the Women's Health Initiative linked hormone therapy to higher risk of stroke, blood clots, breast cancer and probable dementia in older women. Use the lowest dose that works and review it with your provider regularly. Not for anyone with unexplained vaginal bleeding, a history of breast cancer, blood clots, stroke or liver disease.
This is not a complete list. Your provider will review your health history, medicines and allergies before prescribing, and the pharmacy includes the full prescribing information.